Symbol
Name
ID

Ezh2
enhancer of zeste 2 polycomb repressive complex 2 subunit
MGI:107940

Phenotype annotations related to hematopoietic system

Darker colors indicate more annotations

Human Phenotypes	Purpura	Myelofibrosis	Hemophagocytosis	Acute myeloid leukemia	Myeloproliferative disorder	Extramedullary hematopoiesis	Myelodysplasia	Splenomegaly
Disease(s) Associated with EZH2	Purpura	Myelofibrosis	Hemophagocytosis	Acute myeloid leukemia	Myeloproliferative disorder	Extramedullary hematopoiesis	Myelodysplasia	Splenomegaly
acute myeloid leukemia
myelodysplastic syndrome
myelofibrosis

Mouse Phenotypes

decreased B cell proliferation

decreased uterine NK cell number

decreased thymocyte number

enlarged spleen

increased spleen weight

abnormal B cell differentiation

decreased immature B cell number

abnormal immunoglobulin V(D)J recombination

abnormal pro-B cell morphology

increased double-negative T cell number

decreased double-positive T cell number

increased mean corpuscular hemoglobin

decreased germinal center B cell number

increased germinal center B cell number

decreased pre-B cell number

abnormal spleen morphology

abnormal spleen white pulp morphology

decreased spleen germinal center number

decreased spleen germinal center size

increased spleen germinal center number

increased spleen germinal center size

decreased IgG1 level

decreased IgG2b level

decreased IgG3 level

Availability

Mouse Genotype

Ezh2^em1Jbn/Ezh2⁺

Ezh2^{tm1a(EUCOMM)Wtsi}/Ezh2⁺

Ezh2^tm1.1Nesh/Ezh2^tm1.1Nesh
Cd19^tm1(cre)Cgn/Cd19⁺ (conditional)

Ezh2^tm1Tara/Ezh2^tm1Tara
Tg(Mx1-cre)1Cgn/0 (conditional)

Ezh2^tm1Tara/Ezh2^tm1Tara
Ighg1^tm1(cre)Cgn/Ighg1⁺ (conditional)

Ezh2^tm2Sho/Ezh2^tm2Sho
Tg(Mx1-cre)1Cgn/0 (conditional)

Ezh2^tm2Sho/Ezh2^tm2Sho
Pgr^tm2(cre)Lyd/Pgr⁺ (conditional)

Ezh2^tm1.1Nesh/Ezh2⁺
Cd19^tm1(cre)Cgn/Cd19⁺ (conditional)

Col1a1^{tm1(CAG-Ezh2*)Meln}/Col1a1⁺
Ighg1^tm1(cre)Cgn/Ighg1⁺ (conditional)

Ezh2^tm2Sho/Ezh2^tm2.1Sho
Tg(Mx1-cre)1Cgn/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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